Unemployment Rate in St. Louis City, MO was 4.60% in February of 2024, according to the United States Federal Reserve. Historically, Unemployment Rate in St. Louis City, MO reached a record high of 13.80 in May of 2020 and a record low of 2.50 in September of 2022. Trading Economics provides the current actual value, an historical data chart and related indicators for Unemployment Rate in St. Louis City, MO - last updated from the United States Federal Reserve on May of 2024.